New recommendations released for treatment of IBS
A Drug to Treat IBS-C?
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Is there a new medicine that replaces Zelnorm yet? I have IBS with constipation and GERD and was taking Zelnorm, Amitiza, Nexium, and Lactulose (all two times daily), and that worked great for me. But after Zelnorm was found to cause heart attacks, I have been off it and have had major constipation.
No, there is no specific replacement for Zelnorm at this time. Reglan may help you, as may an osmotic laxative like milk of magnesia, or Miralax. Citrate of magnesium is another good choice.
Editor's note:In March 2007, the FDA issued a public health advisory stating that Novartis Pharmaceuticals Corporation had agreed to take Zelnorm (tegaserod maleate) off the market because a safety analysis found that patients taking the drug had a higher risk of having a heart attack, stroke, or worsening chest pain that could lead to a heart attack compared with patients treated with a placebo pill they thought was Zelnorm. Until that time, Zelnorm had been approved for short-term treatment of women with irritable bowel syndrome with constipation and for patients younger than age 65 with chronic constipation. The total number of patients on Zelnorm who actually had heart attacks or severe chest pain that turned into a heart attack was small, but these side effects were considered serious and potentially life-threatening.
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