The ideal chemotherapeutic agent should be aimed at destroying only malignant cells. Unfortunately, there are few such funds. The most commonly used chemotherapeutic agents and their side effects.
The main routes of administration are intravenous and the drug is taken orally. For frequent administration over a long period, a subcutaneous implantation of a venous catheter (central or peripheral), a multi-line catheter or a peripherally inserted central catheter is required.
Chemotherapy can develop resistance, the mechanisms of which are ultra-high expression of target genes, inactivation of the drug by tumor cells, disruption of apoptosis mechanisms in tumor cells, loss of receptors for hormonal drugs. One of the most studied mechanisms is the ultra-high expression of the gene MDR-1, a membrane transporter, which causes the release of certain drugs from cells (for example, vinca alkaloids, taxanes, anthracyclines).Attempts to terminate the function of MDR-1 and thus prevent drug resistance have so far failed.
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